|
T-Cell Prolymphocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We compared the results of parallel analyses of Vβ expression by FCM and TRB rearrangements by DNA-based next-generation sequencing (NGS) in 80 diagnostic peripheral blood samples of patients with T-cell prolymphocytic leukemia (T-PLL) for (1) the diagnosis of clonality and (2) the assessment of dominant Vβ usage.
|
30414304 |
2018 |
|
Systemic Scleroderma
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
TCRBV20S1 and TCRBV3S1 gene segment polymorphisms in systemic sclerosis.
|
18412309 |
2008 |
|
Sezary Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We have examined in detail the features of the T-cell receptor beta (TCRB) gene rearrangements in 20 individuals with well-defined stages of cutaneous T-cell lymphoma (CTCL) comprising 10 cases with early-stage mycosis fungoides (MF) and 10 cases with late-stage MF or Sezary syndrome.
|
16741518 |
2006 |
|
Sezary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
The lack of clear stereotypic TCRA and TCRB CDR3 amino acid motifs would argue against involvement of a single common antigen in the pathogenesis of SS.
|
21410672 |
2011 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Our previous studies have disclosed that the peripheral T cell receptor beta (TCRB) gene repertoires of RA monozygotic twins were similar.
|
9409647 |
1997 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Ten TCRB allelic polymorphisms were analyzed from 3 groups of white women: 112 with RA, 72 with systemic lupus erythematosus, and 70 healthy controls.All participants were also HLA typed.
|
8651986 |
1996 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These results argue against the hypothesis that TCRB polymorphisms play a crucial role in the susceptibility for RA.
|
7979596 |
1994 |
|
Rheumatoid Arthritis
|
0.050 |
Biomarker
|
disease |
LHGDN |
Clonally expanded CD4+CD28null T cells in rheumatoid arthritis use distinct combinations of T cell receptor BV and BJ elements.
|
12594835 |
2003 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These linkage studies provide no significant evidence of a major germline-encoded TCRA or TCRB component of susceptibility to RA.
|
9336413 |
1997 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Dominant Variable (V) and Joining (J) gene pair rearrangements in cancer cells were confirmed by polymerase chain reaction (PCR) amplification and Sanger sequencing; clonality assessment of clinical isolates using BIOMED-2 methods showed agreement for 73% and 77% of samples at the β and γ loci, respectively, whereas β locus V and J allele prevalence in PBMCs were well correlated with results from commercial PCR-based DNA sequencing assays (<i>r</i><sup>2</sup> = 0.94 with Adaptive ImmunoSEQ, 0.77-0.83 with Invivoscribe LymphoTrack TRB Assay).
|
30530777 |
2018 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Shuffling the deck with CTLA-4 therapy: Deep sequencing of rearranged TCRB genes demonstrates T cell repertoire remodeling in cancer patients.
|
29632706 |
2018 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Molecular characterization of a t(7;19)(q34;p13) in a pediatric T-cell acute lymphoblastic leukemia patient led to the identification of a translocation between the TRB@ and LYL1 loci.
|
22058201 |
2012 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
FusionGene
|
disease |
ORPHANET |
|
|
|
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL), activating mutations of NOTCH1 are observed in more than 50% of cases, whereas the t(7;9)(q34;q34) involving NOTCH1 at 9q34 and TRB@ at 7q34 is an extremely rare but recurrent translocation.
|
23033986 |
2013 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Using a combination of molecular cytogenetic and large-scale expression analysis in human T-cell acute lymphoblastic leukemias (T-ALLs), we identified and characterized a new recurrent chromosomal translocation, targeting the major homeobox gene cluster HOXA and the TCRB locus.
|
15774621 |
2005 |
|
Precursor B-cell lymphoblastic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
A large series of 202 childhood precursor-B cell acute lymphoblastic leukemia (ALL) patients was analyzed by Southern blotting (SB) for cross-lineage rearrangements and/or deletions in the T cell receptor TCRB, TCRG and TCRD loci.
|
10025893 |
1999 |
|
Peripheral T-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The lack of CD3 and TCRAB membrane expression on otherwise phenotypically normal mature T lymphocytes together with the absence of detectable TCRBV mRNA and clonal rearrangement of TCRB gene suggested that the abnormal lymphocyte population was the expression of a peripheral T-cell lymphoma with an indolent clinical course.
|
8608231 |
1996 |
|
Periodontal Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
PCR products from both the PBL and periodontal tissue of CAPD patients were cloned and sequenced; analysis of the nucleotide sequence revealed diversity with respect to the expression of TCRB joining (TCRBJ) and TCRB diversity (TCRBD) genes and the sequence of the junctional region in all samples analysed.
|
9395100 |
1997 |
|
Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Genotypic analysis showed that the tumors were B-lineage and clonal, with rearrangements of the Ig heavy- and kappa light-chain loci and no rearrangements of the T-cell receptor beta locus.
|
9376569 |
1997 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Simultaneous detection of TCRA/D or TCRB breaks was achieved in a multicolor approach, which was further combined with detection of the T-cell-specific CD3 antigen in a multicolor FICTION (Fluorescence Immunophenotyping and Interphase Cytogenetics as a Tool for the Investigation of Neoplasm) assay.
|
12682631 |
2003 |
|
Neoplasm, Residual
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
As expected, HTS of TCRB and TCRG identified MRD that was not detected by flow cytometry in a subset of cases (25 of 35 HTS compared with 13 of 35, respectively), which highlights the potential of this technology to define lower detection thresholds for MRD that could affect clinical treatment decisions.
|
22593176 |
2012 |
|
Neoplasm, Residual
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
In conclusion, TCRB gene rearrangements occur in 35% of precursor-B-ALL patients and are relatively stable and sensitive PCR targets for detection of minimal residual disease, particularly if this concerns complete Vbeta-(Dbeta)-Jbeta rearrangements.
|
15470492 |
2004 |
|
Neoplasm, Residual
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The occurrence of the different types of TCRB rearrangement patterns has implications for PCR-based clonality assessment and for PCR-based detection of minimal residual disease via TCRB gene analysis.
|
10360387 |
1999 |
|
Mycosis Fungoides
|
0.050 |
Biomarker
|
group |
BEFREE |
Lymph node TCRB gene analysis provides additional prognostic information for patients with mycosis fungoides with intermediate LN histopathology.
|
9487207 |
1998 |
|
Mycosis Fungoides
|
0.050 |
Biomarker
|
group |
BEFREE |
There is limited information regarding the performance characteristics and utility of TCRG and TCRB clonality assays in diagnosis of MF and ID from paraffin-embedded tissue sections.
|
20203005 |
2010 |